NCALD as a potential predictive biomarker for the efficacy of platinum-based chemotherapy in ovarian cancer

Konrad, Sarah M.; Schwamborn, Kristina; Krueger, Achim; Honert, Katja; Schmitt, Manfred; Hellmann, Daniela; Schmalfeldt, Barbara; Meindl, Alfons; Kiechle, Marion; Quante, Anne S.; Brambs, Christine; Grill, Sabine und Ramser, Juliane (2022): NCALD as a potential predictive biomarker for the efficacy of platinum-based chemotherapy in ovarian cancer. In: Biomarkers in Medicine, Bd. 16, Nr. 14: S. 1029-1041

Abstract

Aim: Since reliable response predictors to platinum-based chemotherapy in ovarian cancer (OC) are scarce, we characterize NCALD as a predictive biomarker. Materials & methods: NCALD mRNA (n = 100) and protein (n = 102) expression was analyzed in OC samples and associated with patient outcome. A stable OC cell line knockdown was generated and cellular response to platinum was explored. Results: High NCALD mRNA and protein expression was significantly associated with longer overall patient survival (p = 0.037/0.002). Knockdown experiments revealed a significant association between cisplatin sensitivity and NCALD expression. Conclusion: Low NCALD expression was associated with reduced sensitivity to platinum-based chemotherapy. NCALD may be a new biomarker candidate to identify patients who might benefit from platinum-based chemotherapy.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1752-0363
• Sprache: Englisch