Modification Tadalafil and Macitentan tablets to aerosol

Zarogoulidis, Paul; Petridis, Dimitris; Sardeli, Chrysa; Kosmidis, Christoforos; Tsakiridis, Kosmas; Matthaios, Dimitris; Huang, Haidong; Bai, Chong; Hohenforst-Schmidt, Wolfgang; Pitsiou, Georgia; Kioumis, Ioannis; Giannakoulas, George; Petanidis, Savas und Karapantzou, Chrysanthi (2022): Modification Tadalafil and Macitentan tablets to aerosol. In: Frontiers in Bioscience-Landmark, Bd. 27, Nr. 1, 19

Abstract

Introduction: Aerosolised drugs have been approved for several diseases such as cystic fibrosis and diabetes. Moreover;there are already drugs for pulmonary hypertension in aerosol form already on the market. Materials and methods: Two drugs for pulmonary hypertension (Tadalafil and Macitentan) were milled and transformed from tablets to powder. Three different jet-nebulizers with seven different residual cups were combined. Moreover, we used 3 different ultrasound nebulizers with two different release methods. Results: The drug and residual cup designs produce alone or jointly different MMAD diameters. The three large (10 mls) residual cups with the jet-nebulisers produced the smallest aerosol droplets. Both ultrasound nebulisers are capable of producing optimal size aerosol droplets <= 5 mu m mmad. Conclusions: These two drugs can be easily administered as aerosol and an vivo clinical study will prove the safety for the airways.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2768-6701
• Sprache: Englisch