Predicting the effectiveness of high-flow oxygen therapy in COVID-19 patients: a single-centre observational study

Schmidt, Felicitas; Nowak, Lorenz; Obereisenbuchler, Florian; Hetrodt, Justin; Heiss-Neumann, Marion; Schoenlebe, Anna; Heinig-Menhard, Katharina; Gesierich, Wolfgang; Behr, Juergen; Hatz, Rudolf A.; Dinkel, Julien und Stoleriu, Mircea-Gabriel (2022): Predicting the effectiveness of high-flow oxygen therapy in COVID-19 patients: a single-centre observational study. In: Anaesthesiology Intensive Therapy, Bd. 54, Nr. 1: S. 12-17

Abstract

Background: High-flow nasal cannula (HFNC) therapy is a helpful tool in the treatment of hypoxaemic respiratory failure. However, the clinical parameters predicting the effectiveness of HFNC in coronavirus-19 disease (COVID-19) patients remain unclear. Methods: Sixteen COVID-19 patients undergoing HFNC in the Asklepios Lung Clinic Munich-Gauting, Germany between 16 March and 3 June 2020 were retrospectively included into the study. Seven patients successfully recovered after HFNC (Group 1), while 9 patients required intubation upon HFNC failure (Group 2). Relevant predictors for an effective HFNC therapy were analysed on day 0 and 4 after HFNC initiation via receiver operating characteristics. Results: The groups did not differ significantly in terms of age, sex, body mass index, and comorbidities. Five patients died in Group 2 upon disease progression and HFNC failure. Group 1 required a lower oxygen supplementation (FiO(2) 0.46 [0.31-0.54] vs. 0.72 [0.54-0.76], P = 0.022) and displayed a higher PaO2/FiO(2) ratio (115 [111-201] vs. 93.3 [67.2-145], P = 0.042) on day 0. In Group 2, fever persisted on day 4 (38.5 [38.0-39.4]degrees C vs. 36.5 [31.1-37.1]degrees C, P = 0.010). Serum C-reactive protein (CRP) levels > 108 mg L-1 (day 0) and persistent oxygen saturation < 89% and PaO2/FiO(2) ratio < 91 (day 4) were identified as significant predictors for HFNC failure (area under curve 0.929, 0.933, and 0.893). Conclusions: Elevated oxygen saturation, decreased FiO(2) and reduced serum CRP on day 4 significantly predict HFNC effectiveness in COVID-19 patients. Based on these parameters, larger prospective studies are necessary to further investigate the effectiveness of HFNC in the treatment of COVID-19-associated hypoxaemic respiratory failure.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1642-5758
• Sprache: Englisch