Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle

Stasi, Michele; Monferrer, Alba; Babl, Leon; Wunnava, Sreekar; Dirscherl, Christina Felicitas; Braun, Dieter; Schwille, Petra; Dietz, Hendrik und Boekhoven, Job (2022): Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle. In: Journal of the American Chemical Society, Bd. 144, Nr. 48: S. 21939-21947

Abstract

Molecular machines, such as ATPases or motor proteins, couple the catalysis of a chemical reaction, most commonly hydrolysis of nucleotide triphosphates, to their conformational change. In essence, they continuously convert a chemical fuel to drive their motion. An outstanding goal of nanotechnology remains to synthesize a nano-machine with similar functions, precision, and speed. The field of DNA nanotechnology has given rise to the engineering precision required for such a device. Simultaneously, the field of systems chemistry developed fast chemical reaction cycles that convert fuel to change the function of molecules. In this work, we thus combined a chemical reaction cycle with the precision of DNA nanotechnology to yield kinetic control over the conformational state of a DNA hairpin. Future work on such systems will result in out-of-equilibrium DNA nanodevices with precise functions.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Physik
• Fakultätsübergreifende Einrichtungen: Center for NanoScience (CENS)
• Themengebiete: 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften ; 500 Naturwissenschaften und Mathematik > 530 Physik
• ISSN: 0002-7863
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 411722921