Abstract
Purpose: An increased risk to develop cancer is one of the most challenging negative side effects of long-term immunosuppression in organ transplant recipients and impaired cancer immunosur-veillance is assumed as underlying mechanism. This study aims to elucidate transplant-related changes in the tumor immune micro-environment (TME) of cancer. Experimental Design: Data from 123 organ transplant recipients (kidney, heart, lung, and liver) were compared with historic data from non-immunosuppressed patients. Digital image analysis of whole-section slides was used to assess abundance and spatial distribution of T cells and tertiary lymphoid structures (TLS) in the TME of 117 tumor samples. Expression of programmed cell death 1 ligand 1 (PD-L1) and human-leucocyte-antigen class I (HLA-I) was assessed on tissue microarrays. Results: We found a remarkably reduced immune infiltrate in the center tumor (CT) regions as well as the invasive margins (IM) of post-transplant cancers. These differences were more pronounced in the IM than in the CT and larger for CD8 thorn T cells than for CD3 thorn T cells. The Immune-score integrating results from CT and IM was also lower in transplant recipients. Density of TLS was lower in cancer samples of transplant recipients. The fraction of samples with PD-L1 expression was higher in controls whereas decreased expression of HLA-I was more common in transplant recipients. Conclusions: Our study demonstrates the impact of immunosup-pression on the TME and supports impaired cancer immunosurveil-lance as important cause of post-transplant cancer. Modern immu-nosuppressive protocols and cancer therapies should consider the distinct immune microenvironment of post-transplant malignancies.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
ISSN: | 1078-0432 |
Sprache: | Englisch |
Dokumenten ID: | 115032 |
Datum der Veröffentlichung auf Open Access LMU: | 02. Apr. 2024, 08:09 |
Letzte Änderungen: | 02. Apr. 2024, 08:09 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 325827080 |