Abstract
Physical activity (PA) promotes the proliferation of neural stem cells and enhances neurogenesis in the dentate gyrus resulting in hippocampal circuit remodeling and cognitive enhancement. Nonetheless, knowledge of other neural progenitors affected by PA and the mechanisms through which they could contribute to circuit plasticity and cognitive enhancement are still poorly understood. In this work we demonstrated that NG2-glia, also known as oligodendrocyte progenitor cells, show enhanced proliferation and differentiation in response to voluntary PA in a brain region-dependent manner in adult mice. Surprisingly, preventing NG2-glia differentiation during enhanced PA abolishes the exercise-associated cognitive improvement without affecting neurogenesis or baseline learning capacity. Thus, here we provided new evidence highlighting the requirement of oligodendrogenesis for exercise induced-cognition enhancement.
Item Type: | Journal article |
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Research Centers: | Graduate School of Systemic Neurosciences (GSN) |
Subjects: | 500 Science > 500 Science |
ISSN: | 0894-1491 |
Language: | English |
Item ID: | 115339 |
Date Deposited: | 02. Apr 2024 08:13 |
Last Modified: | 02. Apr 2024 08:13 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 251293561 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 118803580 |