Critical functions of N- 6-adenosine methylation of mRNAs in T cells*

Ito-Kureha, Taku und Heissmeyer, Vigo (2022): Critical functions of N- 6-adenosine methylation of mRNAs in T cells*. In: Biochimica et Biophysica Acta - Molecular Cell Research, Bd. 1870, Nr. 1, 119380

Abstract

The existence of N6-adenosine methylation (m6A) of mRNA has been known for a long time, but only recently its regulatory potential was uncovered. Current research deciphers the molecular determinants leading to the deposition of this modification and consequences for modified mRNAs. It also evaluates the importance of such modifications for specific cell types and programs. In this review, we summarize the current knowledge on m6A modification of mRNAs in conventional and regulatory T cells and T-cell-driven immune responses and pathology. We discuss the impact of m6A modification on T cell activation including cytokine and antigen receptor signaling or sensing of double-stranded RNAs (dsRNA).

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0167-4889
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 444891219
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 432656284
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 210592381
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 313381103