Characterizing cognitive subtypes in schizophrenia using cortical curvature

Papazova, Irina ; Wunderlich, Stephan; Papazov, Boris; Vogelmann, Ulrike; Keeser, Daniel ; Karali, Temmuz; Falkai, Peter ; Rospleszcz, Susanne ; Maurus, Isabel ; Schmitt, Andrea; Hasan, Alkomiet; Malchow, Berend und Stöcklein, Sophia (2024): Characterizing cognitive subtypes in schizophrenia using cortical curvature. In: Journal of Psychiatric Research, Bd. 173: S. 131-138

Abstract

Cognitive deficits are a core symptom of schizophrenia, but research on their neural underpinnings has been challenged by the heterogeneity in deficits’ severity among patients.

Here, we address this issue by combining logistic regression and random forest to classify two neuropsychological profiles of patients with high (HighCog) and low (LowCog) cognitive performance in two independent samples. We based our analysis on the cortical features grey matter volume (VOL), cortical thickness (CT), and mean curvature (MC) of N = 57 patients (discovery sample) and validated the classification in an independent sample (N = 52). We investigated which cortical feature would yield the best classification results and expected that the 10 most important features would include frontal and temporal brain regions. The model based on MC had the best performance with area under the curve (AUC) values of 76% and 73%, and identified fronto-temporal and occipital brain regions as the most important features for the classification. Moreover, subsequent comparison analyses could reveal significant differences in MC of single brain regions between the two cognitive profiles. The present study suggests MC as a promising neuroanatomical parameter for characterizing schizophrenia cognitive subtypes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie ; Medizin > Klinikum der LMU München > Klinik und Poliklink für Psychiatrie und Psychotherapie ; Medizin > Klinikum der LMU München > Klinik und Poliklinik für Radiologie
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 00223956
• Sprache: Englisch