Homogeneous Heat Transfer During Freeze-Drying Using Cyclic Olefin Polymer Vials

Groël, Sebastian ; Roncin, Hugo; Härdter, Nicole und Winter, Gerhard (2024): Homogeneous Heat Transfer During Freeze-Drying Using Cyclic Olefin Polymer Vials. In: Journal of Pharmaceutical Sciences, Bd. 113, Nr. 9: S. 2947-2951

Abstract

In pharmaceutical freeze-drying processes, batch homogeneity is an important quality attribute. In this context, the edge-vial-effect is a challenging phenomenon. Shortly, this effect describes that vials at the edges of the shelf dry faster and at a higher temperature compared to vials in the middle of the shelf. Studies by Ehlers et al. revealed that this effect mainly origins from the number of neighbor vials cooling each other, which is reduced for vials in corners and edges compared to vials in the middle. Due to the reduced heat transfer in cyclic olefin polymer (COP) vials, the adverse edge-vial-effect should be greatly reduced allowing a better batch uniformity. In this focused study, glass and COP vials are compared regarding this effect on a fully loaded shelf. A reference experiment with vials placed at distance using a specially designed frame is presented as well.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0022-3549
• Sprache: Englisch