A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles

Kiewiet, M. B. Gea; Lupinek, Christian; Vrtala, Susanne ; Wieser, Sandra; Baar, Alexandra; Kiss, Renata; Kull, Inger ; Melén, Erik ; Wickman, Magnus; Porta, Daniela ; Gori, Davide; Gehring, Ulrike ; Aalberse, Rob ; Sunyer, Jordi; Standl, Marie ; Heinrich, Joachim ; Waiblinger, Dagmar; Wright, John; Antó, Josep M.; Bousquet, Jean ; Hage, Marianne van und Valenta, Rudolf (2023): A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles. In: Allergy, Bd. 78, Nr. 7: S. 2007-2018

Abstract

Background: Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalised treatment and prevention strategies in allergy. Methods: IgE sensitization profiles were determined in more than 2800 sera from children in 9 population-based cohorts in different geographical regions of Europe; north (BAMSE (Sweden), ECA (Norway)), west/central (PIAMA (the Netherlands), BiB (UK), GINIplus (Germany)), and south (INMA Sabadell and Gipuzkoa (Spain) and ROBBIC Rome and Bologna (Italy)) using the MeDALL-allergen chip. Results: Sensitization to grass pollen allergen, Phl p 1, and to major cat allergen, Fel d 1, dominated in most European regions whereas sensitization to house dust mite allergens Der p 1, 2 and 23 varied considerably between regions and were lowest in the north. Less than half of children from Sabadell which has a hot and dry climate were sensitized to respiratory allergens, in particular house dust mite allergens as compared to Gipuzkoa nearby with a more humid climate. Peanut allergen Ara h 1 was the most frequently recognized class 1 food allergen in Northern/Western Europe, while the fruit allergens Pru p 3, Act d 1 and 2 were prominent in Southern and Western/Central Europe. Ves v 5-sensitization dominated in North and West/Central Europe. Conclusion: We show regional, exposome and climate-dependent differences in molecular IgE-reactivity profiles in Northern, Western/Central and Southern Europe which may form a molecular basis for precision medicine-based approaches for treatment and prevention of allergy.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0105-4538
• Sprache: Englisch