Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Qi, Qibin; Downer, Mary K.; Kilpeläinen, Tuomas O.; Taal, H. Rob; Barton, Sheila J.; Ntalla, Ioanna; Standl, Marie ; Boraska, Vesna; Huikari, Ville; Kiefte-de Jong, Jessica C.; Körner, Antje; Lakka, Timo A.; Liu, Gaifen; Magnusson, Jessica; Okuda, Masayuki; Raitakari, Olli; Richmond, Rebecca; Scott, Robert A. ; Bailey, Mark E.S.; Scheuermann, Kathrin; Holloway, John W. ; Inskip, Hazel; Isasi, Carmen R.; Mossavar-Rahmani, Yasmin; Jaddoe, Vincent W.V.; Laitinen, Jaana; Lindi, Virpi; Melén, Erik ; Pitsiladis, Yannis; Pitkänen, Niina; Snieder, Harold ; Heinrich, Joachim ; Timpson, Nicholas J. ; Wang, Tao; Yuji, Hinoda; Zeggini, Eleftheria ; Dedoussis, George V.; Kaplan, Robert C.; Wylie-Rosett, Judith; Loos, Ruth J.F.; Hu, Frank B. und Qi, Lu (2015): Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents. In: Diabetes, Bd. 64, Nr. 7: S. 2467-2476

Abstract

The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10(-4)), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10(-4)): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10(-10)) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0012-1797
• Sprache: Englisch