Abstract
Objectives: Gestational diabetes mellitus (GDM) is a growing health concern. Since members of the galectinfamily are identified to play a role in the pathogenesis of GDM, we determined galectin-12 as an essential protein due to its influence in lipolysis and inflammation processes. This study investigates the expression of galectin-12 in the placentas of women with GDM. Study design: The study population includes 40 expectant women suffering from GDM and 40 healthy controls. The expression of galectin-12 in the syncytiotrophoblast (SCT) and the extra villous trophoblast (EVT) of the placenta was analyzed by immunohistological staining and double immunofluorescence. Immunoreactivity Score (IRS) was used for evaluation. Results: The results demonstrate a significant overexpression of galectin-12 in the nucleus of the SCT and the EVT of placentas with GDM compared to the healthy control group. Additionally, double immunofluorescence visualizes corresponding results with an overexpression of galectin-12 in the extra villous trophoblast of GDM placentas representing maternal cells. Conclusion: This study identifies galectin-12 to be associated with the process of gestational diabetes mellitus. These findings are in correspondence with the involvement of galectin-12 in inflammatory processes. Maternal BMI and male sex seem to be confounder for the expression of galectin-12 in the nuclear syncytiotrophoblast, but not in other parts of the investigated placental areas. Further investigations are necessary to verify the correlation between gestational diabetes mellitus and the expression of galectin-12 in the placenta and to further elucidate its distinct role.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin > Klinikum der LMU München > Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
URN: | urn:nbn:de:bvb:19-epub-120154-7 |
ISSN: | 01650378 |
Sprache: | Englisch |
Dokumenten ID: | 120154 |
Datum der Veröffentlichung auf Open Access LMU: | 27. Aug. 2024, 09:57 |
Letzte Änderungen: | 27. Aug. 2024, 09:57 |