Unresectable biliary tract cancer: Current and future systemic therapy

Zhang, Danmei ; Dorman, Klara; Westphalen, Christoph Benedikt ; Haas, Michael; Ormanns, Steffen ; Neumann, Jens; Seidensticker, Max ; Ricke, Jens; De Toni, Enrico N. ; Klauschen, Frederick; Algül, Hana; Reisländer, Timo; Boeck, Stefan and Heinemann, Volker (2024): Unresectable biliary tract cancer: Current and future systemic therapy. In: European Journal of Cancer, Vol. 203, 114046

Abstract

For decades, treatment of advanced biliary tract cancer (BTC) was confined to the use of chemotherapy. In recent years however, the number of therapeutic options available for patients with unresectable BTC have drastically increased, with immunotherapy and targeted treatment gradually joining the ranks of guideline-recommended treatment regimens. The aim of the present review is to summarise the current knowledge on unresectable BTC focusing on epidemiology, anatomical distribution and current strategies for systemic treatment. We further outline ongoing clinical trials and provide an outlook on future therapeutic interventions. In the realm of gastrointestinal malignancies, the increasing number of systemic treatment options for BTC is finally delivering on the longstanding commitment to personalised oncology. This emphasises the need for considering a comprehensive genomic-based pathology assessment right from the initial diagnosis to fully leverage the expanding array of therapeutic options that have recently become accessible.

• Item Type: Journal article
• Faculties: Medicine > Institute of Pathology; Medicine > Medical Center of the University of Munich > Medical Clinic and Outpatient Clinic II (Gastroenterology, Hepatology); Medicine > Medical Center of the University of Munich > Medical Clinic and Outpatient Clinic III (Oncology); Medicine > Medical Center of the University of Munich > Clinic and Polyclinic for Radiology
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 09598049
• Language: English