Five-year mortality in patients with COPD and Impaired left ventricular filling

Abdo, Mustafa; Watz, Henrik; Alter, Peter ; Kahnert, Kathrin ; Trudzinski, Franziska ; Groth, Espen E.; Claussen, Martin; Kirsten, Anne-Marie; Welte, Tobias ; Jörres, Rudolf A. ; Bals, Robert; Vogelmeier, Claus; Rabe, Klaus. F und Waschki, Benjamin (2024): Five-year mortality in patients with COPD and Impaired left ventricular filling. In: European Respiratory Journal, Bd. 64, Nr. Suppl. 68, PA2956

Abstract

Objective To determine if adding performance on the five-repetition sit-to-stand test (5-STS) to chronic obstructive pulmonary disease (COPD) high-risk criteria, proposed by the Spanish COPD guidelines (GesEPOC), affects mortality prognosis.

Methods Observational study of COPD outpatients involved prospective follow-up for 5 years. Patients were classified based on 5-STS performance and risk criteria proposed by GesEPOC version 2021. Outcome measures were 5-year mortality timing and rate. Kaplan–Meier curves and univariate and multivariate Cox proportional-hazard analyses, analysis of variance, and univariate and multivariate linear and logistic regression models were used.

Results One hundred and thirty-seven patients were included. Mean age was 66 ± 8.3 years, and 87.6% were men. Of them, 115 (83.9%) were classified as high risk, 43 (34.4%) of whom had poor performance on the 5-STS. Overall mortality at 5 years was 27% and was significantly higher in the high-risk (29.6%) compared with the low-risk (13.6%) group. Among high-risk patients, mortality at 5 years was significantly worse with poor 5-STS performance (60.5%) compared with non-poor performance (11.1%). Poor performance on the 5-STS was independently associated with increased 5-year mortality risk (HR 4.70; 95% CI: 1.96–11.27) in a model adjusted for history of heart disease and dyspnea.

Conclusion Among high-risk COPD patients, those with poor performance on the 5-STS have a significantly higher mortality at 5 years than those with non-poor 5-STS performance.

• Dokumententyp: Zeitschriftenartikel
• Keywords: COPD; GesEPOC; Mortality; Prognosis; Risk; Physical performance; Five-repetition sit-to-stand test; 5-STS; Heart disease
• Fakultät: Medizin > Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch