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Schöning, Jonas ORCID logoORCID: https://orcid.org/0009-0008-3837-205X; Tekath, Aileen ORCID logoORCID: https://orcid.org/0000-0002-5836-5139; Cornelissen, Nicolas V. ORCID logoORCID: https://orcid.org/0000-0002-3625-7612; Hoffmann, Arne ORCID logoORCID: https://orcid.org/0009-0004-8635-0657 und Rentmeister, Andrea ORCID logoORCID: https://orcid.org/0000-0002-3107-4147 (2025): SAM-III aptamer enables detection of enzymatic SAM analogue generation. In: Chemical Communications, Bd. 61, Nr. 2: S. 370-373 [PDF, 928kB]

Abstract

S-Adenosyl-L-methionine (SAM) is crucial for methylation and tightly controlled in cells. We examined SAM-III riboswitch response to 17 SAM analogues and used a Spinach/SAM aptasensor to monitor their enzymatic formation in situ. Most SAM analogues were recognized, unless they featured an ortho-substituted benzyl ring, indicating potential regulatory effects via SAM riboswitches.

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