ORCID: https://orcid.org/0009-0008-3837-205X; Tekath, Aileen ORCID: https://orcid.org/0000-0002-5836-5139; Cornelissen, Nicolas V. ORCID: https://orcid.org/0000-0002-3625-7612; Hoffmann, Arne ORCID: https://orcid.org/0009-0004-8635-0657 und Rentmeister, Andrea ORCID: https://orcid.org/0000-0002-3107-4147
(2025):
SAM-III aptamer enables detection of enzymatic SAM analogue generation.
In: Chemical Communications, Bd. 61, Nr. 2: S. 370-373
[PDF, 928kB]
Abstract
S-Adenosyl-L-methionine (SAM) is crucial for methylation and tightly controlled in cells. We examined SAM-III riboswitch response to 17 SAM analogues and used a Spinach/SAM aptasensor to monitor their enzymatic formation in situ. Most SAM analogues were recognized, unless they featured an ortho-substituted benzyl ring, indicating potential regulatory effects via SAM riboswitches.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Chemie und Pharmazie > Department Chemie |
| Themengebiete: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| URN: | urn:nbn:de:bvb:19-epub-124741-9 |
| ISSN: | 1359-7345 |
| Bemerkung: | First published 02 Dec 2024 |
| Sprache: | Englisch |
| Dokumenten ID: | 124741 |
| Datum der Veröffentlichung auf Open Access LMU: | 14. Mrz. 2025 11:22 |
| Letzte Änderungen: | 14. Mrz. 2025 11:22 |
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