Triggering of myocardial infarction by heat exposure is modified by medication intake

Chen, Kai ; Dubrow, Robert; Breitner, Susanne; Wolf, Kathrin; Linseisen, Jakob; Schmitz, Timo; Heier, Margit; Scheidt, Wolfgang von ; Kuch, Bernhard; Meisinger, Christa ; Peters, Annette ; Schwettmann, Lars; Leidl, Reiner ; Linkohr, Birgit; Grallert, Harald; Gieger, Christian und Schneider, Alexandra (2022): Triggering of myocardial infarction by heat exposure is modified by medication intake. In: Nature Cardiovascular Research, Bd. 1, Nr. 8: S. 727-731

Abstract

Acute myocardial infarction (MI) can be triggered by heat exposure, but it remains unknown whether patients taking certain cardiovascular medications have elevated vulnerability. Based on a validated and complete registration of all 2,494 MI cases in Augsburg, Germany, during warm seasons (May to September) from 2001 to 2014, here we show that heat-related non-fatal MI risk was elevated among users of anti-platelet medication and beta-receptor blockers, respectively, but not among non-users, with significant differences between users and non-users. We also found that these effect modifications were stronger among younger patients (25–59 years), who had a lower prevalence of pre-existing coronary heart disease (CHD, a potential confounder by indication), than among older patients (60–74 years), who had a higher prevalence of pre-existing CHD. Users of these medications may be more vulnerable than non-users to non-fatal MI risk due to heat exposure. Further research is needed to disentangle effect modification by medication use from effect modification by pre-existing CHD.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Betriebswirtschaft > Institut für Gesundheitsökonomie und Management im Gesundheitswesen
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2731-0590
• Sprache: Englisch