ORCID: https://orcid.org/0000-0003-4236-8025; Ficklscherer, Andreas ORCID: https://orcid.org/0000-0003-1957-3055; Niethammer, Thomas R. ORCID: https://orcid.org/0000-0001-7810-3235; Woiczinski, Matthias; Davies-Knorr, Patricia; Holzapfel, Boris M. und Müller, Peter E.
(2024):
Comparison of Biological Augmentation in Rotator Cuff Repair Using Inflamed Versus Noninflamed Bursal Tissue in Rats.
In: Arthroscopy: The Journal of Arthroscopic & Related Surgery
Abstract
Purpose To examine how augmentation of a rotator cuff repair with inflamed versus noninflamed bursal tissue affects tendon-to-bone healing in a rat model of rotator cuff repair.
Methods A total of 136 Sprague-Dawley rats were randomly assigned to an inflamed or noninflamed bursal tissue application group. After detachment, the supraspinatus tendon was reattached with bursal tissue sewn onto the tendon-to-bone interface. The specimens were analyzed biomechanically 6 and at 7 weeks and immunohistologically at 1 and at 7 weeks after surgery.
Results Immunohistological results showed no significant difference in the percentage of collagen type II in the tendon-to-bone interface at 1 (P = .87) and 7 weeks (P = .42) when using autologous noninflamed bursal tissue in comparison with inflamed bursal tissue specimens. The inflamed bursa group also showed no significant difference in collagen I to III quotient (P = .14) after surgery in comparison with noninflamed bursa groups after surgery. Biomechanical assessment showed that tendon stiffness (P = .87 inflamed versus noninflammed (resp.) P = .1) and the tendon viscoelasticity (P = .12 resp. P = .07) was the same after 6 and 7 weeks when we compared the inflamed bursa with the noninflamed bursa group. There was no significant difference (P = .8 resp. P = .87) in load to failure between in both inflamed and noninflamed bursa groups after 6 and 7 weeks.
Conclusions Autologous inflamed bursal tissue derived from the Achilles bursa and implanted to the tendon-to-bone interface after rotator cuff repair facilitates the same histologic and biomechanical healing response as using a noninflamed bursa interposition in rats.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin > Klinikum der LMU München > MUM - Muskuloskelettales Universitätszentrum München |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 07498063 |
| Sprache: | Englisch |
| Dokumenten ID: | 125331 |
| Datum der Veröffentlichung auf Open Access LMU: | 12. Mai 2025 08:36 |
| Letzte Änderungen: | 12. Mai 2025 08:36 |
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