The impact of endocrine disrupting chemicals on adrenal corticosteroids – A systematic review of epidemiological studies

Stüfchen, Isabel ; Schweizer, Júnia R.O.L.; Völter, Friederike ; Nowak, Elisabeth ; Braun, Leah T. ; Kocabiyik, Julien ; Mederos y Schnitzler, Michael; Williams, Tracy Ann ; Kunz, Sonja ; Bidlingmaier, Martin und Reincke, Martin (1. Juli 2025): The impact of endocrine disrupting chemicals on adrenal corticosteroids – A systematic review of epidemiological studies. In: Environmental Research, Bd. 276, 121438

Abstract

Background

The role of endocrine disrupting chemicals (EDCs) in the development of metabolic syndrome has gained increasing recognition in recent years. The underlying mechanisms are largely unresolved. Disruption of corticosteroid action and hypothalamic-pituitary-adrenal (HPA) axis are considered possible mechanisms.

Objective

To summarise epidemiological studies investigating an association between EDC concentration and altered levels of corticosteroids and the adrenocorticotropic hormone (ACTH).

Methods

Following the PRISMA guidelines, we searched PubMed and the Cochrane Library for epidemiological studies published from database inception until April 1st, 2024. Various groups of EDCs were evaluated with the prerequisite of direct measurement of the chemical, a metabolite, or biomarker.

Results

We identified 2094 articles. After removing duplicates and screening, 27 studies were included. Studies focused predominantly on glucocorticoids (n = 26) compared to mineralocorticoids (n = 5) and ACTH (n = 2). The most studied EDCs were pesticides (n = 9) and phthalates (n = 8). Significant associations between the concentrations of specific EDCs and hormone levels were found in all but three studies. Only one study described an association between EDCs, and hormone concentration and metabolic features.

Conclusion

There is clear evidence for the impact of specific EDCs on plasma corticosteroid concentrations in different age groups worldwide, however, results varied according to EDC class, study population and study methodology. Further research combining EDC and hormone concentrations, and clinical features, complemented by experimental investigations to study cell mechanisms, is needed to gain holistic knowledge of EDCs’ influence on glucocorticoid- and mineralocorticoid-related disorders.

• Dokumententyp: Zeitschriftenartikel
• EU Funded Grant Agreement Number: 694913
• EU-Projekte: Horizon 2020
• Fakultät: Medizin > Walther-Straub-Institut für Pharmakologie und Toxikologie ; Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik V (Pneumologie)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 00139351
• Sprache: Englisch