Novel approaches to CAR T cell target identification in acute myeloid leukemia

Hoffmann, Gordon Victor ; Gottschlich, Adrian ; Subklewe, Marion und Kobold, Sebastian (Juni 2025): Novel approaches to CAR T cell target identification in acute myeloid leukemia. In: Current Opinion in Pharmacology, Bd. 82, 102524

Abstract

Identifying safe and effective CAR T cell targets in acute myeloid leukemia (AML) is challenging due to the disease’s complexity and overlap with normal hematopoiesis. This review highlights advances in target discovery for AML, emphasizing innovative approaches. Structural surfaceomics identifies tumor-specific protein conformations, while AI-driven single-cell RNA sequencing integrates multi-source data to pinpoint optimal targets. Refined cell surface capture technology maps the AML surfaceome without relying on predefined antibodies. These strategies enhance CAR T cell specificity and minimize off-tumor effects, offering promising pathways for safer and more effective AML treatments and broader cancer therapies.

• Dokumententyp: Zeitschriftenartikel
• EU Funded Grant Agreement Number: 955575
• Fakultät: Medizin > Walther-Straub-Institut für Pharmakologie und Toxikologie ; Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik III (Onkologie)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 14714892
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 452881907