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Eijkemans, Marianne ORCID logoORCID: https://orcid.org/0000-0003-4550-8628; Mommers, Monique ORCID logoORCID: https://orcid.org/0000-0002-6341-3596; Harskamp-van Ginkel, Margreet W ORCID logoORCID: https://orcid.org/0000-0001-8792-6663; Vrijkotte, Tanja G M ORCID logoORCID: https://orcid.org/0000-0003-3641-4048; Ludvigsson, Johnny ORCID logoORCID: https://orcid.org/0000-0003-1695-5234; Faresjö, Ashild ORCID logoORCID: https://orcid.org/0000-0003-0723-139X; Bergström, Anna ORCID logoORCID: https://orcid.org/0000-0002-7981-6314; Ekstöm, Sandra ORCID logoORCID: https://orcid.org/0000-0002-2060-8190; Grote, Veit ORCID logoORCID: https://orcid.org/0000-0001-7168-2385; Koletzko, Berthold ORCID logoORCID: https://orcid.org/0000-0002-5345-7165; Bonnelykke, Klaus ORCID logoORCID: https://orcid.org/0000-0003-2003-1018; Eliasen, Anders Ulrik ORCID logoORCID: https://orcid.org/0000-0003-2629-0790; Bager, Peter ORCID logoORCID: https://orcid.org/0000-0002-3577-8459; Melbye, Mads ORCID logoORCID: https://orcid.org/0000-0001-8264-6785; Annesi-Maesano, Isabella ORCID logoORCID: https://orcid.org/0000-0002-6340-9300; Baiz, Nour ORCID logoORCID: https://orcid.org/0000-0001-6165-3935; Barros, Henrique ORCID logoORCID: https://orcid.org/0000-0003-4699-6571; Santos, Ana Cristina ORCID logoORCID: https://orcid.org/0000-0002-2992-5299; Duijts, Liesbeth ORCID logoORCID: https://orcid.org/0000-0001-6731-9452; Mensink-Bout, Sara M ORCID logoORCID: https://orcid.org/0000-0002-5381-6287; Flexeder, Claudia ORCID logoORCID: https://orcid.org/0000-0003-3974-1482; Koletzko, Sibylle ORCID logoORCID: https://orcid.org/0000-0003-2374-8778; Schikowski, Tamara ORCID logoORCID: https://orcid.org/0000-0002-4559-9374; Eggesbo, Merete Ase ORCID logoORCID: https://orcid.org/0000-0002-0006-5336; Lenters, Virissa ORCID logoORCID: https://orcid.org/0000-0002-0444-9150; Fernandez-Tardon, Guillermo ORCID logoORCID: https://orcid.org/0000-0002-7680-158X; Subiza-Perez, Mikel ORCID logoORCID: https://orcid.org/0000-0002-6843-8557; Garcia-Aymerich, Judith ORCID logoORCID: https://orcid.org/0000-0002-7097-4586; Lopez-Vicente, Monica ORCID logoORCID: https://orcid.org/0000-0002-5090-7538; Sunyer, Jordi ORCID logoORCID: https://orcid.org/0000-0002-2602-4110; Torrent, Maties ORCID logoORCID: https://orcid.org/0000-0001-8728-3741; Ballester, Ferran ORCID logoORCID: https://orcid.org/0000-0002-6165-3465; Kelleher, Cecily ORCID logoORCID: https://orcid.org/0000-0001-9548-4914; Mehegan, John ORCID logoORCID: https://orcid.org/0000-0002-4229-3599; Berg, Andrea von ORCID logoORCID: https://orcid.org/0000-0003-0168-1541; Herberth, Gunda ORCID logoORCID: https://orcid.org/0000-0003-0212-3509; Standl, Marie ORCID logoORCID: https://orcid.org/0000-0002-5345-2049; Kuehni, Claudia E ORCID logoORCID: https://orcid.org/0000-0001-8957-2002; Pedersen, Eva S L ORCID logoORCID: https://orcid.org/0000-0003-0293-9954; Jansen, Maria ORCID logoORCID: https://orcid.org/0000-0002-1843-139X; Gehring, Ulrike ORCID logoORCID: https://orcid.org/0000-0003-3612-5780; Boer, Jolanda M A ORCID logoORCID: https://orcid.org/0000-0002-9714-4304; Devereux, Graham ORCID logoORCID: https://orcid.org/0000-0002-0024-4887; Turner, Steve ORCID logoORCID: https://orcid.org/0000-0001-8393-5060; Peltola, Ville ORCID logoORCID: https://orcid.org/0000-0003-3529-2747; Lagström, Hanna ORCID logoORCID: https://orcid.org/0000-0002-5069-6582; Inskip, Hazel M ORCID logoORCID: https://orcid.org/0000-0001-8897-1749; Pike, Katharine C ORCID logoORCID: https://orcid.org/0000-0003-4911-6082; Dalmeijer, Geertje W ORCID logoORCID: https://orcid.org/0000-0002-9048-6635; Ent, Cornelis K van der und Thijs, Carel ORCID logoORCID: https://orcid.org/0000-0001-6646-5458 (2024): Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis. In: BMJ Open Respiratory Research, Bd. 11, Nr. 1, e001630 [PDF, 3MB]

Abstract

Objectives:

To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.

Design:

Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.

Setting:

Children aged 0–18 years from 26 European birth cohorts.

Participants:

136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.

Main outcome measure Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6–18 years.

Results:

Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3–5 years was not associated with asthma at age 6–18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.

Conclusions:

Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.

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