ORCID: https://orcid.org/0000-0002-6798-2630; Rospleszcz, Susanne
ORCID: https://orcid.org/0000-0002-4788-2341; Matthiessen, Clara; Hoffmann, Barbara
ORCID: https://orcid.org/0000-0002-8435-5575; Stoecklein, Sophia
ORCID: https://orcid.org/0000-0003-0325-4674; Haueise, Tobias
ORCID: https://orcid.org/0000-0002-1462-7539; Norajitra, Tobias; Schlett, Christopher L.; Nattenmüller, Johanna; Bamberg, Fabian; Machann, Jürgen; Günther, Matthias
ORCID: https://orcid.org/0000-0002-2650-7956; Hirsch, Jochen; Nagrant, Rajini
ORCID: https://orcid.org/0000-0002-1708-2319; Völzke, Henry
ORCID: https://orcid.org/0000-0001-7003-399X; Meinke-Franze, Claudia
ORCID: https://orcid.org/0000-0001-6137-9702; Hosten, Norbert
ORCID: https://orcid.org/0000-0002-4149-5666; Nonnenmacher, Tobias; Budai, Bettina Katalin
ORCID: https://orcid.org/0000-0002-3982-7887; Palm, Viktoria
ORCID: https://orcid.org/0000-0002-4369-6752; Katzke, Verena
ORCID: https://orcid.org/0000-0002-6509-6555; Greiser, Karin Halina
ORCID: https://orcid.org/0000-0003-3213-8285; Schulz-Menger, Jeanette; Niendorf, Thoralf
ORCID: https://orcid.org/0000-0001-7584-6527; Endemann, Beate; Pischon, Tobias
ORCID: https://orcid.org/0000-0003-1568-767X; Staab, Jeroen; Dallavalle, Marco
ORCID: https://orcid.org/0000-0002-6986-3934; Schneider, Alexandra
ORCID: https://orcid.org/0000-0002-1084-2442; Wolf, Kathrin
ORCID: https://orcid.org/0000-0002-4343-201X und Peters, Annette
ORCID: https://orcid.org/0000-0001-6645-0985
(2025):
Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO).
In: Environment International, Bd. 201, 109566
[PDF, 4MB]
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Abstract
Little is known about the relation between traffic noise exposure, an established environmental risk factor for cardiovascular disease, and early obesity-related risk markers such as adipose tissue (AT) and hepatic fat. Therefore, we aimed to assess associations of long-term road traffic noise exposure with AT depots measures from whole-body magnetic resonance imaging (MRI). We analyzed cross-sectional data from 11,343 participants from the population-based German National Cohort (NAKO) who underwent MRI examination between 2014 and 2016, considering visceral (VAT), subcutaneous abdominal (SCAAT), subcutaneous thoracic AT (SCTAT) and hepatic fat content as outcomes. Annual road traffic noise (Lden) data from the year 2017 (source: central EIONET data repository) was used to calculate weighted mean noise levels on a continuous scale within 10 and 100-meter buffers of participants’ residencies. Among 11,101 participants with complete outcome data, 48.7 % were women, and the mean age was 51.9 years. Higher annual Lden was associated with increased AT depots and hepatic fat content in men (e.g., VAT: 1.72 %-change [95 % confidence interval: [0.14 %; 3.30 %]; SCAAT: 2.18 %-change [0.43 %; 3.93 %], hepatic fat content: 3.57 %-change [1.41 %; 5.78 %] per 10 dB(A) increase in Lden (10 m)) and women (e.g., VAT: 3.13 %-change [1.09 %; 5.18 %]; SCAAT: 2.38 %-change [0.55 %; 4.20 %], hepatic fat content: 3.08 %-change [1.00 %; 5.21 %] per 10 dB(A) increase in Lden (10 m)). Associations were robust with all outcomes after adjusting for air pollutants and surrounding greenness, and effect modification by obesity and hypertension was observed for SCAAT, SCTAT and hepatic fat content. Our findings indicate that annual exposure to road traffic noise is associated with increased adipose tissue depots and hepatic fat content, and thus present novel evidence for the cross-sectional association between noise and early MRI-derived metabolic health markers.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin > Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
URN: | urn:nbn:de:bvb:19-epub-128271-0 |
ISSN: | 01604120 |
Sprache: | Englisch |
Dokumenten ID: | 128271 |
Datum der Veröffentlichung auf Open Access LMU: | 03. Sep. 2025 07:30 |
Letzte Änderungen: | 03. Sep. 2025 07:30 |