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Semmler, Marie ORCID logoORCID: https://orcid.org/0009-0003-5634-3627; Brinkmann, Isabel; Aydogdu, Can; Pyrgidis, Nikolaos ORCID logoORCID: https://orcid.org/0000-0002-7707-8426; Kidess, Marc; Ebner, Benedikt ORCID logoORCID: https://orcid.org/0000-0003-2126-7305; Ledderose, Stephan ORCID logoORCID: https://orcid.org/0000-0001-7313-2088; Stief, Christian G. ORCID logoORCID: https://orcid.org/0000-0003-3291-9460; Marcon, Julian; Apfelbeck, Maria ORCID logoORCID: https://orcid.org/0000-0002-9223-9291 und Chaloupka, Michael ORCID logoORCID: https://orcid.org/0000-0002-8814-6412 (2025): Resection of a singular metachronous testicular metastasis of prostate cancer: A case report. In: Current Problems in Cancer: Case Reports, Bd. 18, 100370 [PDF, 3MB]

Abstract

We present the case of a 66-year-old patient with a biochemical recurrence of prostate cancer manifesting as an asymptomatic testicular metastasis. Two years after radical prostatectomy and salvage radiation, the prostate-specific antigen (PSA) level rose to 1.07ng/ml. PSMA PET/CT scan showed tracer accumulation in the left testicle. Inguinal orchiectomy confirmed the metastasis. After being non-detectable, the PSA level increased five months after orchiectomy, with PSMA PET/CT revealing positive iliac lymph nodes. In summary, the presented case illustrates orchiectomy as a metastasectomy. However, apart from a transient decrease in PSA, no medium-term oncological advantage could be seen.

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