ORCID: https://orcid.org/0000-0002-6047-334X; Teodorescu, Bianca ORCID: https://orcid.org/0000-0002-4333-5965; Gilberg, Leonard; Schäfer, Arlett ORCID: https://orcid.org/0000-0002-8010-594X; Beyer, Georg ORCID: https://orcid.org/0000-0002-7607-8264; Arnau, Anna; López-Guillén, Pablo; Martínez-Domínguez, Samuel J.; Baroja, Daniel Abad ORCID: https://orcid.org/0000-0001-8372-9590; Oyón, Daniel ORCID: https://orcid.org/0000-0001-8648-3944; Ruiz-Belmonte, Lara M.; Tejedor-Tejada, Javier ORCID: https://orcid.org/0000-0002-3585-5733; Zapater, Raul; Martín-Vicente, Noelia ORCID: https://orcid.org/0009-0002-5682-1441; Fernández-Esparcia, Pedro José; Gomara, Ana Belén Julián; Lozano, Violeta Sastre; García, Juan José Manzanares; Martín-Falquina, Irene Chivato; Pascual, Laura Andrés; Monclus, Nuria Torres ORCID: https://orcid.org/0000-0001-5603-1816; Velasco, Natividad Zaragoza; Rojo, Eukene ORCID: https://orcid.org/0000-0002-3706-8266; Lapeña-Muñoz, Berta; Flores, Virginia; Gómez, Arantxa Díaz; Cañamares-Orbís, Pablo ORCID: https://orcid.org/0000-0002-7283-2370; Abizanda, Isabel Vinzo; Carrasco, Natalia Marcos; Grau, Laura Pardo; García-Rayado, Guillermo; Bocos, Judith Millastre; de Paredes, Ana Garcia Garcia; Lorenzo, María Vaamonde ORCID: https://orcid.org/0000-0002-3913-3412; Arostegi, Arantzazu Izagirre ORCID: https://orcid.org/0000-0001-8886-8995; Lozada-Hernández, Edgard Efrén ORCID: https://orcid.org/0000-0001-8614-9516; Velasco, José Antonio Velarde-Ruiz; Żorniak, Michal; de-Madaria, Enrique ORCID: https://orcid.org/0000-0002-2412-9541; Mayerle, Julia ORCID: https://orcid.org/0000-0002-3666-6459 und Velamazán, Raúl
(2025):
Lower rate of pancreatobiliary complications after sludge and microlithiasis pancreatitis compared to gallstone pancreatitis.
In: Digestive and Liver Disease, Bd. 57, Nr. 9: S. 1810-1818
[PDF, 1MB]
Abstract
Background and Aims
Cholecystectomy is recommended to prevent recurrence of biliary pancreatitis, but supporting evidence is limited for sludge- and microlithiasis-induced acute pancreatitis (AP). This study aimed to compare relapse patterns and risk factors between patients with sludge/microlithiasis-induced AP and gallstone-induced AP.
Methods
This analysis included 789 patients from the international, multicenter Relapstone cohort (Spain: 16 centers; Mexico: 2 centers), hospitalized between January 2018 and April 2020 with first-time biliary AP and no cholecystectomy during admission. Patients with sludge/microlithiasis-induced AP (n = 274) were compared to those with gallstone-induced AP (n = 515) regarding pancreatobiliary complications. Multivariate analysis was used to assess relapse risk factors.
Results
Pancreatobiliary complications occurred in 41.7 % of the gallstone cohort versus 32.1 % in the sludge/microlithiasis cohort (p = 0.01). Correspondingly, the gallstone AP cohort showed a significantly lower complication-free survival rate (log-rank p = 0.0022; median follow-up: 6.1 vs. 8.1 months). In multivariate analysis, older age in the gallstone group was significantly associated with lower relapse risk (HR = 0.54, 95 % CI: 0.39–0.74).
Conclusion
This multicenter study reveals distinct differences in relapse risk between gallstone- and sludge/microlithiasis-induced AP, with gallstone AP showing a higher rate of complications in the absence of cholecystectomy.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik II (Gastroenterologie, Hepatologie) |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| URN: | urn:nbn:de:bvb:19-epub-128929-4 |
| ISSN: | 15908658 |
| Sprache: | Englisch |
| Dokumenten ID: | 128929 |
| Datum der Veröffentlichung auf Open Access LMU: | 21. Okt. 2025 05:33 |
| Letzte Änderungen: | 21. Okt. 2025 05:33 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 413635475 |
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