ORCID: https://orcid.org/0000-0002-7795-1395; Schober, Laura; Fischer, Alessa ORCID: https://orcid.org/0000-0003-4555-8334; Bechmann, Nicole ORCID: https://orcid.org/0000-0002-6932-333X; Maurer, Julian; Peischer, Lea; Reul, Astrid; Hantel, Constanze ORCID: https://orcid.org/0009-0000-8906-2563; Reincke, Martin ORCID: https://orcid.org/0000-0002-9817-9875; Beuschlein, Felix ORCID: https://orcid.org/0000-0001-7826-3984; Robledo, Mercedes ORCID: https://orcid.org/0000-0001-6256-5902; Mohr, Hermine ORCID: https://orcid.org/0000-0002-3061-1166; Pellegata, Natalia S.; Schilbach, Katharina ORCID: https://orcid.org/0000-0002-8667-0296; Knösel, Thomas; Ilmer, Matthias; Angele, Martin; Kroiss, Matthias; Maccio, Umberto; Broglie-Däppen, Martina; Vetter, Diana; Lehmann, Kuno ORCID: https://orcid.org/0000-0002-6177-9543; Pacak, Karel ORCID: https://orcid.org/0000-0002-3541-3767; Grossman, Ashley B.; Auernhammer, Christoph J. ORCID: https://orcid.org/0000-0001-8087-3722; Zitzmann, Kathrin ORCID: https://orcid.org/0009-0001-2341-3161 und Nölting, Svenja ORCID: https://orcid.org/0000-0002-7064-590X
(12. April 2024):
Opposing Effects of Cannabidiol in Patient-derived Neuroendocrine Tumor, Pheochromocytoma/Paraganglioma Primary Cultures.
In: Journal of Clinical Endocrinology & Metabolism, Bd. 109, Nr. 11: S. 2892-2904
Abstract
Context: Treatment options for advanced neuroendocrine tumors (NETs), pheochromocytomas and paragangliomas (PPGLs) are still limited. In recent years, antitumor effects of cannabinoids have been reported; however, there are only very limited data available in NETs or PPGLs.
Objective: Investigation of the effects of cannabidiol (CBD) on patient-derived human NET/PPGL primary cultures and on NET/PPGL cell lines.
Methods: We established primary cultures derived from 46 different patients with PPGLs (n = 35) or NETs (n = 11) who underwent tumor resection at 2 centers. Treatment of patient primary cultures with clinically relevant doses (5 µM) and slightly higher doses (10 µM) of CBD was performed.
Results: We found opposing effects of 5 µM CBD: significant antitumor effects in 5/35 (14%) and significant tumor-promoting effects in 6/35 (17%) of PPGL primary cultures. In terms of antitumor effects, cluster 2-related PPGLs showed significantly stronger responsivity to CBD compared to cluster 1-related PPGLs (P = .042). Of the cluster 2-related tumors, NF1 PPGLs showed the strongest responsivity (4/5 PPGL primary cultures with a significant decrease in cell viability were NF1-mutated). We also found opposing effects of 10 µM CBD in PPGLs and NETs: significant antitumor effects in 9/33 of PPGL (27%) and 3/11 of NET (27%) primary cultures and significant tumor-promoting effects in 6/33 of PPGL (18%) and 2/11 of NET (18%) primary cultures.
Conclusion: We suggest a potential novel treatment option for some NETs/PPGLs but also provide evidence for caution when applying cannabinoids as supportive therapy for pain or appetite management to cancer patients and possibly as health supplements.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik IV (Endokrinologie, Nephrologie, weitere Sektionen) |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 0021-972X |
| Sprache: | Englisch |
| Dokumenten ID: | 130090 |
| Datum der Veröffentlichung auf Open Access LMU: | 11. Dez. 2025 16:10 |
| Letzte Änderungen: | 11. Dez. 2025 16:10 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 314061271 |
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