First-line pazopanib in patients with metastatic epithelioid hemangioendothelioma: a retrospective single-center analysis

Burkhard-Meier, Anton ; Rechenauer, Vera Valerie; Jurinovic, Vindi ; Albertsmeier, Markus ; Hoberger, Michael; Dürr, Hans Roland ; Klein, Alexander ; Knösel, Thomas ; Kunz, Wolfgang G. ; Mock, Andreas; Pusztai, Ada; Völkl, Michael; Bergwelt-Baildon, Michael von ; Lindner, Lars H. ; Di Gioia, Dorit und Berclaz, Luc M. (2025): First-line pazopanib in patients with metastatic epithelioid hemangioendothelioma: a retrospective single-center analysis. In: Journal of Cancer Research and Clinical Oncology, Bd. 151, Nr. 4, 150

Abstract

Purpose: Epithelioid hemangioendothelioma (EHE) represents an ultra-rare, translocated vascular sarcoma with a heterogeneous course of disease. The optimal systemic treatment for patients with advanced EHE remains unclear. We sought to evaluate the value of pazopanib (PAZ) as a first-line treatment in metastatic EHE.

Methods: Thirteen patients with metastatic EHE and PAZ as a first-line treatment at our institution between 2012 und 2023 were reviewed and analyzed with regard to clinical outcomes.

Results: At a median follow-up of 51.4 months, the median progression-free survival (PFS) and overall survival (OS) were 35.1 and 53.8 months, respectively. In patients with documented prior tumor progression (n = 10), the median PFS and OS were 12.6 and 105 months, respectively. In patients with serosal effusion/ systemic symptoms (n = 4), the median PFS and OS were 6.1 and 10.3 months. The clinical benefit rate of the overall cohort was 62% with no complete or partial responses. Two of four patients experienced a reduction of symptoms (pain and ascites reduction/hemoptysis, respectively) under treatment with PAZ. Toxicity was mainly gastrointestinal and manageable with dose reductions. Permanent treatment interruption due to toxicity was necessary in one patient.

Conclusion: This is the first study to systematically report survival outcomes for PAZ as a first-line treatment in patients with metastatic EHE. PAZ is active and safe in patients with metastatic EHE and may be considered as an alternative to sirolimus for specific patient subgroups. RECIST criteria should be questioned for evaluation of treatment response in EHE.

• Dokumententyp: Zeitschriftenartikel
• Keywords: Epithelioid hemangioendothelioma · Rare cancers · Metastasis · Pazopanib · Targeted therapy
• Fakultät: Medizin > Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie ; Medizin > Klinikum der LMU München > Klinik für Allgemeine, Viszeral-, Gefäß- und Transplantationschirurgie ; Medizin > Klinikum der LMU München > Medizinische Klinik und Poliklinik III (Onkologie) ; Medizin > Klinikum der LMU München > Klinik und Poliklinik für Radiologie
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1432-1335
• Sprache: Englisch