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Ziegler, Andreas; Kastner, C. (1997): A Minimum Distance Estimation Approach to Estimate the Recombination Fraction from a Marker Locus in Robust Linkage Analysis for Quantitative Traits. Collaborative Research Center 386, Discussion Paper 65
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Olson and Wijsman (1993) have proposed a robust linkage analysis between quantitative traits and a marker locus using all relative pairs. We extend their work to estimate the recombination fraction using minimum distance estimation after robust linkage analysis requiring a single marker locus. The relevant parameters of the genetic model can also be estimated in the presence of linkage. We illustrate our approach by simulations.