GABA increases electrical excitability in a subset of human unmyelinated peripheral axons

Carr, Richard W; Sittl, Ruth; Fleckenstein, Johannes and Grafe, Peter (20. January 2010): GABA increases electrical excitability in a subset of human unmyelinated peripheral axons.
In: PLOS ONE 5(1), e8780

Abstract

A proportion of small diameter primary sensory neurones innervating human skin are chemosensitive. They respond in a receptor dependent manner to chemical mediators of inflammation as well as naturally occurring algogens, thermogens and pruritogens. The neurotransmitter GABA is interesting in this respect because in animal models of neuropathic pain GABA pre-synaptically regulates nociceptive input to the spinal cord. However, the effect of GABA on human peripheral unmyelinated axons has not been established.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1932-6203
• Language: English