Effective Improvement of Symptoms in Patients with Acute Migraine by GR43175 Administered in Dispersible Tablets

Dönicke, A.; Melchart, D. and Bayliss, E.M. (1989): Effective Improvement of Symptoms in Patients with Acute Migraine by GR43175 Administered in Dispersible Tablets. In: Cephalalgia, Vol. 9, No. 9 Suppl.: pp. 89-92

Abstract

GR43175, a selective 5-HT1-like agonist, was administered as oral dispersible tablets in an open, uncontrolled dose-ranging study to assess its efficacy as an agent for acute migraine. Nine patients, all with well established attacks, were assessed for changes in severity of headache and associated symptoms over 2 h. Drug absorption was compared during and between attacks in five patients. Doses of 140 mg and 280 mg resulted in complete relief of all symptoms within 2 h. Treatment was well tolerated in all patients.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: ISSN 0800-1952
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English