MIRTFnet: analysis of miRNA regulated transcription factors.

Naeem, Haroon; Küffner, Robert; Zimmer, Ralf (2011): MIRTFnet: analysis of miRNA regulated transcription factors.
In: PLOS ONE 6(8), e22519

Abstract

Several expression datasets of miRNA transfection experiments are available to analyze the regulatory mechanisms downstream of miRNA effects. The miRNA induced regulatory effects can be propagated via transcription factors (TFs). We propose the method MIRTFnet to identify miRNA controlled TFs as active regulators if their downstream target genes are differentially expressed.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Mathematics, Computer Science and Statistics > Computer Science
• Subjects: 000 Computer science, information and general works > 004 Data processing computer science
• ISSN: 1932-6203
• Language: English