Lang, Claudia; Guo, Xiaoli; Kerschensteiner, Martin; Bareyre, Florence M.
Single collateral reconstructions reveal distinct phases of corticospinal remodeling after spinal cord injury.
In: PloS one
Injuries to the spinal cord often result in severe functional deficits that, in case of incomplete injuries, can be partially compensated by axonal remodeling. The corticospinal tract (CST), for example, responds to a thoracic transection with the formation of an intraspinal detour circuit. The key step for the formation of the detour circuit is the sprouting of new CST collaterals in the cervical spinal cord that contact local interneurons. How individual collaterals are formed and refined over time is incompletely understood.