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Becker, Klaus; Eder, Matthias; Ranft, Andreas; Meyer, Ludwig von; Zieglgänsberger, Walter; Kochs, Eberhard und Dodt, Hans-Ulrich (2012): Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
In: PLOS ONE 7(6), e39346




The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity.