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Borasio, Gian Domenico (2006): Carbamazepine-responsive paroxysmal nausea and vomiting in a patient with meningeal carcinomatosis. In: Palliative Medicine, Vol. 20, No. 5: pp. 549-550




In neurology, paroxysmal syndromes are well-known, eg, as manifestations of multiple sclerosis. We report a patient with meningeal carcinomatosis, who presented with therapyrefractory nausea and vomiting. The clinical suspicion of a paroxysmal syndrome prompted a trial of carbamazepine, which resulted in complete cessation of the symptoms. In cancer patients with central nervous system (CNS) involvement and therapy-refractory symptoms with sudden onset, carbamazepine treatment should be considered.