In: PLOS ONE
5(3), e9468
[PDF, 2MB]
Abstract
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced body weight, partial resistance to age- or diet-induced obesity, and overall improved metabolic status. Alteration in the liver gene expression profile, in behavior and metabolism point to a calorie restriction-like phenotype in Eps8 knockout mice. Additionally, and consistent with a calorie restricted metabolism, Eps8 knockout mice show increased lifespan. The metabolic alterations in Eps8 knockout mice correlated with a significant reduction in intestinal fat absorption presumably caused by a 25% reduction in intestinal microvilli length. Our findings implicate actin dynamics as a novel variable in the determination of longevity. Additionally, our observations suggest that subtle differences in energy balance can, over time, significantly affect bodyweight and metabolic status in mice.
Item Type: | Journal article |
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Form of publication: | Publisher's Version |
Faculties: | Veterinary Medicine > Department of Veterinary Medicine > Lehrstuhl für Molekulare Tierzucht und Biotechnologie |
Subjects: | 500 Science > 570 Life sciences; biology |
URN: | urn:nbn:de:bvb:19-epub-15683-2 |
ISSN: | 1932-6203 |
Language: | English |
Item ID: | 15683 |
Date Deposited: | 21. Jun 2013, 13:06 |
Last Modified: | 04. Nov 2020, 12:56 |