Tocchetti, Arianna; Soppo, Charlotte Blanche Ekalle; Zani, Fabio; Bianchi, Fabrizio; Gagliani, Maria Cristina; Pozzi, Benedetta; Rozman, Jan; Elvert, Ralf; Ehrhardt, Nicole; Rathkolb, Birgit; Moerth, Corinna; Horsch, Marion; Fuchs, Helmut; Gailus-Durner, Valérie; Beckers, Johannes; Klingenspor, Martin; Wolf, Eckhard; Hrabé de Angelis, Martin; Scanziani, Eugenio; Tacchetti, Carlo; Scita, Giorgio; Di Fiore, Pier Paolo; Offenhäuser, Nina
(2010):
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
In: PLOS ONE 5(3), e9468 |
| 2MB |
Abstract
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced body weight, partial resistance to age- or diet-induced obesity, and overall improved metabolic status. Alteration in the liver gene expression profile, in behavior and metabolism point to a calorie restriction-like phenotype in Eps8 knockout mice. Additionally, and consistent with a calorie restricted metabolism, Eps8 knockout mice show increased lifespan. The metabolic alterations in Eps8 knockout mice correlated with a significant reduction in intestinal fat absorption presumably caused by a 25% reduction in intestinal microvilli length. Our findings implicate actin dynamics as a novel variable in the determination of longevity. Additionally, our observations suggest that subtle differences in energy balance can, over time, significantly affect bodyweight and metabolic status in mice.
Item Type: | Journal article |
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Form of publication: | Publisher's Version |
Faculties: | Veterinary Medicine > Department of Veterinary Medicine > Lehrstuhl für Molekulare Tierzucht und Biotechnologie |
Subjects: | 500 Science > 570 Life sciences; biology |
URN: | urn:nbn:de:bvb:19-epub-15683-2 |
ISSN: | 1932-6203 |
Language: | English |
ID Code: | 15683 |
Deposited On: | 21. Jun 2013 13:06 |
Last Modified: | 04. Nov 2020 12:56 |
- BASE
- Tocchetti, Arianna
- Soppo, Charlotte Blanche Ekalle
- Zani, Fabio
- Bianchi, Fabrizio
- Gagliani, Maria Cristina
- Pozzi, Benedetta
- Rozman, Jan
- Elvert, Ralf
- Ehrhardt, Nicole
- Rathkolb, Birgit
- Moerth, Corinna
- Horsch, Marion
- Fuchs, Helmut
- Gailus-Durner, Valérie
- Beckers, Johannes
- Klingenspor, Martin
- Wolf, Eckhard
- Hrabé de Angelis, Martin
- Scanziani, Eugenio
- Tacchetti, Carlo
- Scita, Giorgio
- Di Fiore, Pier Paolo
- Offenhäuser, Nina
- Google Scholar
- Tocchetti, Arianna
- Soppo, Charlotte Blanche Ekalle
- Zani, Fabio
- Bianchi, Fabrizio
- Gagliani, Maria Cristina
- Pozzi, Benedetta
- Rozman, Jan
- Elvert, Ralf
- Ehrhardt, Nicole
- Rathkolb, Birgit
- Moerth, Corinna
- Horsch, Marion
- Fuchs, Helmut
- Gailus-Durner, Valérie
- Beckers, Johannes
- Klingenspor, Martin
- Wolf, Eckhard
- Hrabé de Angelis, Martin
- Scanziani, Eugenio
- Tacchetti, Carlo
- Scita, Giorgio
- Di Fiore, Pier Paolo
- Offenhäuser, Nina