Abstract
Generalised estimating equations have been well established to draw inference for the marginal mean from follow-up data. Many studies suffer from missing data that may result in biased parameter estimates if the data are not missing completely at random. Robins and coworkers proposed to use weighted estimating equations (WEE) in estimating the mean structure if drop-out occurs missing at random. We illustrate the differences between the WEE and the commonly applied available case analysis in a simulation study. We apply the WEE and re-analyse data on pregnancy and HPV infection. We estimate the response probabilities and demonstrate that the data are not missing completely at random. Upon use of the WEE, we are able to show that pregnant women have an increased odds for an HPV infection compared with study subjects after delivery (p = 0.027). We conclude that the WEE are useful in analysing follow-up data with drop-outs.
Item Type: | Paper |
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Faculties: | Mathematics, Computer Science and Statistics > Statistics > Collaborative Research Center 386 Special Research Fields > Special Research Field 386 |
Subjects: | 500 Science > 510 Mathematics |
URN: | urn:nbn:de:bvb:19-epub-1591-2 |
Language: | English |
Item ID: | 1591 |
Date Deposited: | 05. Apr 2007 |
Last Modified: | 04. Nov 2020, 12:45 |