Abstract
Localized wave fronts are a fundamental feature of biological systems from cell biology to ecology. Here, we study a broad class of bistable models subject to self-activation, degradation, and spatially inhomogeneous activating agents. We determine the conditions under which wave-front localization is possible and analyze the stability thereof with respect to extrinsic perturbations and internal noise. It is found that stability is enhanced upon regulating a positional signal and, surprisingly, also for a low degree of binding cooperativity. We further show a contrasting impact of self-activation to the stability of these two sources of destabilization. DOI: 10.1103/PhysRevLett.110.038102
Dokumententyp: | Zeitschriftenartikel |
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Publikationsform: | Publisher's Version |
Fakultät: | Physik |
Themengebiete: | 500 Naturwissenschaften und Mathematik > 530 Physik |
URN: | urn:nbn:de:bvb:19-epub-16008-0 |
ISSN: | 0031-9007 |
Ort: | ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA |
Sprache: | Englisch |
Dokumenten ID: | 16008 |
Datum der Veröffentlichung auf Open Access LMU: | 25. Jul. 2013, 10:01 |
Letzte Änderungen: | 08. Mai 2024, 08:18 |