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Reisner, Walter; Morton, Keith .J; Riehn, Robert; Wang, Yan Mei; Yu, Zhaoning; Rosen, Michael; Sturm, James C.; Chou, Stephen Y.; Frey, Erwin; Austin, Robert H. (May 2005): Statics and dynamics of single DNA molecules confined in nanochannels. In: Physical Review Letters, Vol. 94, No. 19: 196101-1-196101-4




The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly twice the persistence length there is a crossover in the polymer physics.