Ruzicka, Thomas; Willers, Christoph; Wigger-Alberti, Walter
Efficacy and Patient-Reported Outcomes of a New Mometasone Cream Treating Atopic Eczema.
In: Skin Pharmacology and Physiology, No. 6: pp. 305-312
This double-blind controlled phase II study was conducted to compare a newly developed formulation of mometasone furoate with a water content of 33% (Monovo (R) Cream) and with a smooth consistency versus the commercially available fatty cream of mometasone furoate (Ecural (R) Fettcreme) in terms of efficacy, cosmetic properties, and patients' acceptance. In 20 patients with mild to moderate atopic eczema, the preparations were tested intraindividually in a randomized mode and in two comparable lesion areas. Both preparations were equally effective and well tolerated. Due to improved cosmetic properties, the new formulation was preferred by the patients when asked for preferential use. Quality of life could be improved by treating with both preparations. Copyright (C) 2012 S. Karger AG, Basel