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Dickgreber, Nicolas; Huber, Rudolf M.; Reck, Martin; Reinmuth, Niels; Schütte, Wolfgang; Serke, Monika; Wolf, Jürgen (2010): Aktuelle Entwicklungen und Perspektiven zielgerichteter Therapien. In: Onkologie, No. 5: pp. 2-11




Current Developments and Perspectives in Targeted Therapies Many different approaches for improving the prognosis of patients with advanced non-small-cell lung cancer (NSCLC) are currently being investigated. This article discusses the significance of maintenance therapy after primary chemotherapy and reviews study data on second-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), inhibitors of insulin-like growth factor receptors (IGFR), vascular-disrupting agents (VDAs) and multi-TKIs of vascular endothelial growth factor receptors (VEGFR). The article also looks at the future prospects of using genetic markers in the field of NSCLC.