Antipsychotic Response in the First Week Predicts Later Efficacy

Giegling, Ina; Porcelli, Stefano; Balzarro, Beatrice; Andrisano, Costanza; Schäfer, Martin; Möller, Hans-Jürgen; Rujescu, Dan and Serretti, Alessandro (2012): Antipsychotic Response in the First Week Predicts Later Efficacy. In: Neuropsychobiology, No. 2: pp. 100-105

Abstract

Background and Aims: Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. Methods: 86 acutely psychotic patients treated with haloperidol were studied. Results: A PANSS reduction <= 16% at 1 week predicts non-response at 3 weeks of treatment (specificity 92%, sensitivity 82%). Conversely, a PANSS reduction >= 23% at 1 week of treatment predicts response at 3 weeks, with a specificity of 84% and a sensitivity of 86%. Conclusion: Our results confirm that an early response to antipsychotic treatment accurately predicts the treatment effectiveness and extends it to a prediction performed as early as 1 week. Copyright (c) 2012 S. Karger AG, Basel

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0302-282X
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English