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Giegling, Ina; Porcelli, Stefano; Balzarro, Beatrice; Andrisano, Costanza; Schäfer, Martin; Möller, Hans-Jürgen; Rujescu, Dan and Serretti, Alessandro (2012): Antipsychotic Response in the First Week Predicts Later Efficacy. In: Neuropsychobiology, No. 2: pp. 100-105 [PDF, 251kB]


Background and Aims: Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. Methods: 86 acutely psychotic patients treated with haloperidol were studied. Results: A PANSS reduction <= 16% at 1 week predicts non-response at 3 weeks of treatment (specificity 92%, sensitivity 82%). Conversely, a PANSS reduction >= 23% at 1 week of treatment predicts response at 3 weeks, with a specificity of 84% and a sensitivity of 86%. Conclusion: Our results confirm that an early response to antipsychotic treatment accurately predicts the treatment effectiveness and extends it to a prediction performed as early as 1 week. Copyright (c) 2012 S. Karger AG, Basel

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