Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight

Kemming, Gregor; Messick, J. B.; Mueller, W.; Enders, G.; Meisner, F.; Muenzing, S.; Kisch-Wedel, Hille; Schropp, A.; Wojtczyk, C.; Packert, K.; Messmer, K. und Thein, E. (2004): Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight. In: European Surgical Research, No. 4: pp. 198-205

Abstract

We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock study. The clinical course of the dogs was dramatic including anorexia and hemolytic anemia. Treatment included allogeneic transfusion, prednisone, and oxytetracycline. Systematic follow-up (n=12, blood smears, antibody testing and specific polymerase chain reaction) gives clear evidence that persistent eradication of M. haemocanis is unlikely. We, therefore, had to abandon the intended shock study. In the absence of effective surveillance and screening for M. haemocanis, the question arises whether it is prudent to continue shock research in splenectomized dogs. Copyright (C) 2004 S. Karger AG, Basel.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0014-312X
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English