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Eisensehr, Ilonka; Noachtar, S.; Schlippenbach, C. von; Uttner, I.; Kleine, J.; Seelos, Klaus; Helmchen, C. (2003): Hypersomnia associated with bilateral posterior hypothalamic lesion - A polysomnographic case study. In: European Neurology, No. 3: pp. 169-172




We examined an obese 58-year-old patient with a bilateral posterior hypothalamic lesion of unknown etiology. A 24-hour polysomnography revealed a markedly increased total sleep time (17.6 h). During daytime, only 3 continuous wake phases occurred. REM periods occurred only between 5 p.m. and 6 a.m. We conclude from our results that, similar to the results from animal experiments, the posterior hypothalamus in humans plays a critical role in the maintenance of wakefulness. Copyright (C) 2003 S. Karger AG, Basel.