Protein-carbohydrate interactions during fertilization

Sinowatz, Fred; Plendl, J. und Kolle, S. (1998): Protein-carbohydrate interactions during fertilization. In: Acta Anatomica, No. 1-4: pp. 196-205

Abstract

Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during the primary binding of the sperm to the ZP in different species. Synthesis, structure and composition of the ZP an summarized. The functional significance of carbohydrate residues of the ZP as sperm receptor is discussed. Sperm surface proteins known to have specific ZP and carbohydrate-binding sites including the mouse beta 1,4-galactosyltransferase and sp56, the rabbit protein Sp17, a human mannose-binding protein and several members of the sperm-adhesin family are presented.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0001-5180
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English