Decoding transcription and microRNA-mediated translation control in Drosophila development

Gaul, Ulrike (2010): Decoding transcription and microRNA-mediated translation control in Drosophila development. In: Biological Chemistry, Vol. 391, No. 7: pp. 767-770

Abstract

The spatio-temporal regulation of gene expression lies at the heart of animal development. In this article we present an overview of our recent work to apply systems biological approaches to the study of transcription and microRNA-mediated translation control in Drosophila development. We have identified many new cis-regulatory elements within the segmentation gene network, a transcriptional hierarchy governing pattern formation along the antero-posterior axis of the embryo, and developed a novel thermodynamic model to predict their expression. A similar thermodynamic approach that takes into account the secondary structure of the target mRNA significantly improves the prediction of microRNA binding sites.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1431-6730
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English