Interdependence of kallikrein-related peptidases in proteolytic networks

Beaufort, Nathalie; Plaza, Karolina; Utzschneider, Daniel; Schwarz, Amelie; Burkhart, Julia M.; Creutzburg, Sabine; Debela, Mekdes; Schmitt, Manfred; Ries, Christian und Magdolen, Viktor (2010): Interdependence of kallikrein-related peptidases in proteolytic networks. In: Biological Chemistry, Vol. 391, No. 5: pp. 581-587

Abstract

Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for interconnection of KLKs within extracellular proteolytic networks leading to activation of protease zymogens and found that (i) pro-KLK activation by other KLKs is scarce, with the exception of pro-KLK which is efficiently activated by KLK4 and 5; (ii) pro-KLK4 is activated by matrix metalloproteinase 3; and (iii) trypsin-like KLKs efficiently activate the serine protease urokinase. Our observations provide new insights into the regulation of these important tumor-associated proteases.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1431-6730
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English