Logo
EnglishCookie löschen - von nun an wird die Spracheinstellung Ihres Browsers verwendet.
Gilch, S.; Spielhaupter, C.; Schätzl, H. M. (2000): Shortest known prion protein allele in highly BSE-susceptible lemurs. In: Biological Chemistry, Vol. 381, Nr. 5-6: S. 521-523
[img]
Vorschau

PDF

89kB

Abstract

We describe the shortest prion protein allele known to date. Surprisingly, it is found as a polymorphism exactly in a species (prosimian lemurs) which seems highly susceptible to oral infection with BSE-derived prions. The truncation of the prion protein we found raises several questions. First, is the truncated octarepeat structure we describe, consisting of two octarepeats, still functional in copper binding? A second question is whether this truncation is related to the remarkable oral infectibility of lemurs with BSE-derived prions. And finally, one could argue that this genotype alone might favour development of a prion disease, even in the absence of exogenous infection.