Reduction of circulating cholesterol and apolipoprotein levels during sepsis

Fraunberger, Peter; Schaefer, Steffen; Werdan, Karl; Walli, Autar K. and Seidel, Dietrich (1999): Reduction of circulating cholesterol and apolipoprotein levels during sepsis. In: Clinical Chemistry and Laboratory Medicine, Vol. 37, No. 3: pp. 357-362

Abstract

Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered cholesterol homeostasis. The host response during sepsis is mediated by cytokines and growth factors, which are capable of influencing lipid metabolism. Conversely lipoproteins are also capable of modulating cytokine production during the inflammatory response. Therefore the decrease in circulating cholesterol levels seems to play a crucial role in the pathophysiology of sepsis. In this review the interaction between cytokines and lipid metabolism and its clinical consequences will be discussed.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1434-6621
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English