Partial Least Squares: A Versatile Tool for the Analysis of High-Dimensional Genomic Data

Boulesteix, Anne-Laure und Strimmer, Korbinian (2005): Partial Least Squares: A Versatile Tool for the Analysis of High-Dimensional Genomic Data. Sonderforschungsbereich 386, Discussion Paper 457

Abstract

Partial Least Squares (PLS) is a highly efficient statistical regression technique that is well suited for the analysis of high-dimensional genomic data. In this paper we review the theory and applications of PLS both under methodological and biological points of view. Focusing on microarray expression data we provide a systematic comparison of the PLS approaches currently employed, and discuss problems as different as tumor classification, identification of relevant genes, survival analysis and modeling of gene networks.

• Dokumententyp: Paper
• Fakultät: Mathematik, Informatik und Statistik > Statistik > Sonderforschungsbereich 386 ; Sonderforschungsbereiche > Sonderforschungsbereich 386
• Themengebiete: 500 Naturwissenschaften und Mathematik > 510 Mathematik
• Sprache: Englisch