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Hoppe, Berthold; Häupl, Thomas; Skapenko, Alla; Ziemer, Sabine; Tauber, Rudolf; Salama, Abdulgabar; Schulze-Koops, Hendrik; Burmester, Gerd-Rüdiger; Dörner, Thomas (July 2012): Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation. In: Annals of the rheumatic diseases, Vol. 71, No. 7: pp. 1163-1169




Fibrinogen is a target of autoimmune reactions in rheumatoid arthritis (RA). Fibrin(ogen) derivatives are involved in inflammatory processes and the generation of a stable fibrin network is necessary for sufficient inflammation control. As the density and stability of fibrin networks depend on complex interactions between factor XIIIA (F13A) and fibrinogen genotypes, the authors studied whether these genotypes were related to C-reactive protein (CRP) levels during acute-phase reactions.