Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms

Schulz, Eduard; Valentin, Angelika; Ulz, Peter; Beham-Schmid, Christine; Lind, Karin; Rupp, Verena; Lackner, Herwig; Wölfler, Albert; Zebisch, Armin; Olipitz, Werner; Geigl, Jochen; Berghold, Andrea; Speicher, Michael R. und Sill, Heinz (Juli 2012): Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms. In: Journal of medical genetics, Bd. 49, Nr. 7: S. 422-428

Abstract

Therapy related myeloid neoplasms (t-MNs) are complex diseases originating from an interplay between exogenous toxicities and a susceptible organism. It has been hypothesised that in a subset of cases t-MNs develop in the context of hereditary cancer predisposition syndromes.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1468-6244
• Sprache: Englisch