Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms

Schulz, Eduard; Valentin, Angelika; Ulz, Peter; Beham-Schmid, Christine; Lind, Karin; Rupp, Verena; Lackner, Herwig; Wölfler, Albert; Zebisch, Armin; Olipitz, Werner; Geigl, Jochen; Berghold, Andrea; Speicher, Michael R.; Sill, Heinz (July 2012): Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms. In: Journal of medical genetics, Vol. 49, No. 7: pp. 422-428

Abstract

Therapy related myeloid neoplasms (t-MNs) are complex diseases originating from an interplay between exogenous toxicities and a susceptible organism. It has been hypothesised that in a subset of cases t-MNs develop in the context of hereditary cancer predisposition syndromes.

• Item Type: Journal article
• Form of publication: Publisher's Version
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1468-6244
• Language: English